Five years after they defeated Gozer, the Ghostbusters are out of business. When Dana begins to have ghost problems again, the boys come out of retirement to aid her and hopefully save New York City from a new paranormal threat.
After losing their academic posts at a prestigious university, a team of parapsychologists goes into business as proton-pack-toting "ghostbusters" who exterminate ghouls, hobgoblins and supernatural pests of all stripes. An ad campaign pays off when a knockout cellist hires the squad to purge her swanky digs of demons that appear to be living in her refrigerator.
After an accident at the hair salon, Violet realizes she's not living life to the fullest. A soulful barber helps her put the pieces back together.
Following a ghost invasion of Manhattan, paranormal enthusiasts Erin Gilbert and Abby Yates, nuclear engineer Jillian Holtzmann, and subway worker Patty Tolan band together to stop the otherworldly threat.